Influence of glutathione levels and heat-shock on the steady-state levels of oxidative DNA base modifications in mammalian cells.

@article{Will1999InfluenceOG,
  title={Influence of glutathione levels and heat-shock on the steady-state levels of oxidative DNA base modifications in mammalian cells.},
  author={Oliver Will and Howard C. Mahler and Andr{\'e} Patrick Arrigo and Bernd Epe},
  journal={Carcinogenesis},
  year={1999},
  volume={20 2},
  pages={
          333-7
        }
}
The effects of thiols, ascorbic acid and thermal stress on the basal (steady-state) levels of oxidative DNA base modifications were studied. In various types of untreated cultured mammalian cells, the levels of total glutathione were found to be inversely correlated with the levels of DNA base modifications sensitive to the repair endonuclease Fpg protein, which include 8-hydroxyguanine (8-oxoG). A depletion of glutathione by treatment with buthionine sulphoximine increased the steady-state… CONTINUE READING

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