Influence of glutathione S-transferase M1 and T1 genotypes on larynx cancer risk among Korean smokers.

@article{Hong2000InfluenceOG,
  title={Influence of glutathione S-transferase M1 and T1 genotypes on larynx cancer risk among Korean smokers.},
  author={Young Joon Hong and Jae Kwan Lee and Gyoung Hoon Lee and Seok Il Hong},
  journal={Clinical chemistry and laboratory medicine},
  year={2000},
  volume={38 9},
  pages={917-9}
}
Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of major carcinogens present in tobacco smoke. It is thus conceivable that deficiency in GST activity due to homozygous deletions of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The influence of the GSTM1 and GSTT1 null genotypes on larynx cancer risk among the Korean population were evaluated using peripheral blood DNA from 82 larynx cancer patients and 63… CONTINUE READING

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