Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system

@article{AlKurdi2015InfluenceOG,
  title={Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system},
  author={Zakieh I. Al-Kurdi and B. Chowdhry and S. Leharne and N. Qinna and M. M. A. Al Omari and A. Badwan},
  journal={Drug Design, Development and Therapy},
  year={2015},
  volume={9},
  pages={6167 - 6176}
}
  • Zakieh I. Al-Kurdi, B. Chowdhry, +3 authors A. Badwan
  • Published 2015
  • Medicine
  • Drug Design, Development and Therapy
  • The aim of the work reported herein was to study the effect of glucosamine HCl (GlcN·HCl) on the bioactivity (BA) of insulin, administered via subcutaneous (SC) and oral routes, in adult male Sprague Dawley rats. The oral insulin delivery system (insulin–chitosan reverse micelle [IC-RM]) was prepared by solubilizing insulin–chitosan (13 kDa) polyelectrolyte complex in a RM system consisting of oleic acid, PEG-8 caprylic/capric glycerides, and polyglycerol-6-dioleate. The BA of insulin in vivo… CONTINUE READING

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