Influence of glucocorticoids on human osteoclast generation and activity.

  title={Influence of glucocorticoids on human osteoclast generation and activity.},
  author={Sutharshani Sivagurunathan and M. M. Pattison Muir and Tara C Brennan and John Paul Seale and R S Mason},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={20 3},
UNLABELLED Using human peripheral blood mononuclear cells as osteoclast precursors, we showed that dexamethasone stimulated osteoclast generation at a pharmacological concentration but did not affect the life span of human osteoclasts. Dexamethasone also dose-dependently increased signals for osteoclastogenesis. INTRODUCTION Glucocorticoid-induced osteoporosis is a common and serious disease. Glucocorticoids predominantly affect osteoblast proliferation and life span. Much of the bone loss is… CONTINUE READING


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