Influence of genetics on irritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: a twin study.

@article{Lembo2007InfluenceOG,
  title={Influence of genetics on irritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: a twin study.},
  author={Antony Lembo and Mohammed Khalequ Zaman and M. T. Islwyn Jones and Nicholas J Talley},
  journal={Alimentary pharmacology & therapeutics},
  year={2007},
  volume={25 11},
  pages={1343-50}
}
BACKGROUND A genetic contribution has been proposed for irritable bowel syndrome (IBS) and gastro-oesophageal reflux disease (GERD), but is controversial. No twin data exist for dyspepsia. AIM To determine the relative contribution of genetic factors in GERD, dyspepsia (upper abdominal pain) and IBS. METHODS A total of 986 twin pairs (from initial mail-out response 51%). Both members completed validated symptom and psychological questionnaires; 481 monozygotic pairs [mean (s.d.) age 53… CONTINUE READING

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