Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38.

@article{Paoluzzi2004InfluenceOG,
  title={Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38.},
  author={Luca Paoluzzi and Arun S. Singh and Douglas K. Price and Romano Danesi and Ron H. J. Mathijssen and Jaap Verweij and William D. Figg and Alex Sparreboom},
  journal={Journal of clinical pharmacology},
  year={2004},
  volume={44 8},
  pages={854-60}
}
The uridine diphosphate glucuronosyltransferase (UGT) 1A1 and 1A9 isoforms are involved in the phase II biotransformation of the irinotecan metabolite, SN-38. Recently, several variants in the UGT1A1 and UGT1A9 genes have been described with altered functionality in vitro. The aim of this study was to evaluate the functional consequence of the UGT1A1(TA)(7)TAA (UGT1A1(*)28), UGT1A9 766G>A (D256N; UGT1A9(*)5), and UGT1A9 98T>C (M33T; UGT1A9(*)3) variants in Caucasian patients treated with… CONTINUE READING

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