Influence of food on the disposition of the monoamine oxidase‐A inhibitor brofaromine in healthy volunteers

  title={Influence of food on the disposition of the monoamine oxidase‐A inhibitor brofaromine in healthy volunteers},
  author={P. H. Degen and J-M. Cardot and C Czendlik and Walter Dieterle},
  journal={Biopharmaceutics \& Drug Disposition},
The effect of food on the bioavailability of brofaromine hydrochloride was investigated in a randomized cross‐over study. Eight healthy male volunteers were given single peroral doses of 75 mg brofaromine hydrochloride after overnight fasting or a fat‐ and proteinrich breakfast. Mean (± SD) areas under the plasma concentration‐time curves (AUC) were 9.66 (2.35) μmoll−1 h when given to the fasted volunteers and 11.82 (3.78) μmoll−1 h (p = 0.0413) when given after a substantial breakfast. Mean… 
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