Influence of food on the bioavailability of spironolactone

@article{Overdiek1986InfluenceOF,
  title={Influence of food on the bioavailability of spironolactone},
  author={H W Overdiek and Frans W. H. M. Merkus},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1986},
  volume={40}
}
Nine healthy volunteers received a single oral dose of 200 mg spironolactone, once during fasting conditions and once immediately after a standardized breakfast. Serum concentrations of spironolactone and its metabolites 7α‐thiomethylspirolactone, 6β‐hydroxy‐7α‐thiomethylspirolactone, and canrenone were determined by HPLC for 24 hours after dosing. By taking spironolactone with food, the mean (± SD) AUC (0 to 24 hours) of the parent drug increased from 288 ± 138 (empty stomach) to 493 ± 105 ng… Expand
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