Influence of food on pharmacokinetics of zolpidem from fast dissolving sublingual zolpidem tartrate tablets

  title={Influence of food on pharmacokinetics of zolpidem from fast dissolving sublingual zolpidem tartrate tablets},
  author={D. Greenblatt and J. Harmatz and Nikhilesh N. Singh and T. Roth and S. Harris and R. Kapil},
  journal={The Journal of Clinical Pharmacology},
Ingesting food can impact the pharmacokinetics of sedative‐hypnotic drugs. A buffered zolpidem sublingual tablet (ZST) recently became available for the treatment of middle‐of‐the‐night awakening. In this randomized, open‐label, single‐site study, the pharmacokinetic profile of ZST was evaluated when administered while fasting and following a standard high‐fat meal (fed state). Healthy adults aged 18–64 years received a single morning dose of 3.5 mg ZST in the fed or fasting state. From 20 min… Expand
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Comparison of pharmacokinetic profiles of zolpidem buffered sublingual tablet and zolpidem oral immediate-release tablet: results from a single-center, single-dose, randomized, open-label crossover study in healthy adults.
The initial rate of absorption was faster, and initial systemic exposure was greater, with ZST compared with oral IR, and systemic exposure of zolpidem was higher in females for both formulations. Expand
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Pharmacodynamic measures showed that sublingual and oral alprazolam both produced sedation, fatigue, impaired digit symbol substitution, slowing of reaction time, and impairment of the acquisition and recall of information. Expand
Influence of Food on Midazolam Absorption
In ingestion of midazolam within one hour after a meal may result in a delay in the onset of the pharmacologic effect, and changes in the Cmax, tmax, and AUC parameters for both midAZolam and its metabolite may be of some clinical significance. Expand
Clobazam Kinetics: Intrasubject Variability and Effect of Food on Absorption
Administration of clobazam with food slows the rate of cl obazam absorption but does not alter the completeness of absorption, and the rateof drug elimination is highly replicable upon repeated administration of clOBazam to the same individual. Expand
Diazepam absorption: Effect of antacids and food
Under the conditions of this study, coadministration of diazepam with antacids or a standard meal reduces the rate of absorption but does not reduce extent of absorption. Expand
Absolute Bioavailability and Effect of Food and Antacid on Diazepam Absorption from a Slow‐Release Preparation
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Absence of effect of food on alprazolam absorption from sustained release tablets.
Results indicate that the SR tablet was minimally affected by food, and coefficients of variation for Cmax, tmax, and AUC were somewhat smaller with the SR tablets than with the conventional tablet. Expand
Effect of Dietary Fat Content in Meals on Pharmacokinetics of Quazepam
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Effects of Food on Clinical Pharmacokinetics
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