Influence of flare design on symptomatic efficacy of non-steroidal anti-inflammatory drugs in osteoarthritis: a meta-analysis of randomized placebo-controlled trials.

@article{Trijau2010InfluenceOF,
  title={Influence of flare design on symptomatic efficacy of non-steroidal anti-inflammatory drugs in osteoarthritis: a meta-analysis of randomized placebo-controlled trials.},
  author={Sophie Trijau and J{\'e}r{\^o}me Avouac and C{\'e}cile Escalas and Laure Gossec and Maxime Dougados},
  journal={Osteoarthritis and cartilage},
  year={2010},
  volume={18 8},
  pages={
          1012-8
        }
}
INTRODUCTION Non-steroidal anti-inflammatory drugs' (NSAIDs) symptomatic efficacy in osteoarthritis (OA) is often assessed in trials with a "flare design", i.e., including only patients with an increase in their pain after stopping their usual treatment (NSAIDs or analgesic). OBJECTIVE To evaluate the influence of the "flare design" on NSAIDs apparent symptomatic efficacy in OA. DESIGN SEARCH STRATEGY a systematic literature research was performed in Medline, EMBASE and The Cochrane… CONTINUE READING
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