Influence of extreme obesity on the body disposition and neuromuscular blocking effect of atracurium.

@article{Varin1990InfluenceOE,
  title={Influence of extreme obesity on the body disposition and neuromuscular blocking effect of atracurium.},
  author={France Varin and Julie Ducharme and Yves Th{\'e}{\^o}ret and J. G. Besner and David R. Bevan and François Donati},
  journal={Clinical pharmacology and therapeutics},
  year={1990},
  volume={48 1},
  pages={
          18-25
        }
}
The pharmacokinetics and pharmacodynamics of atracurium, a nondepolarizing neuromuscular blocking agent, were compared between morbidly obese patients and nonobese patients. Atracurium besylate (0.2 mg/kg) was administered intravenously as a bolus to patients who had received anesthesia. The force of contraction of the adductor pollicis was measured and plasma samples were collected for a 2-hour period. The concentrations of atracurium and its major end product, laudanosine, were determined by… CONTINUE READING

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