Influence of experimental diabetes on regulatory mechanisms of vascular response of rabbit carotid artery to acetylcholine.

@article{Miranda2000InfluenceOE,
  title={Influence of experimental diabetes on regulatory mechanisms of vascular response of rabbit carotid artery to acetylcholine.},
  author={Francisco Javier Miranda and Jos{\'e} A Alabad{\'i} and Silvia Llor{\'e}ns and Rosa F Ruiz de Apodaca and Jos{\'e} M. Centeno and Enrique Alborch},
  journal={Life sciences},
  year={2000},
  volume={66 21},
  pages={2071-80}
}
The purpose of this study was to analyse the influence of experimental diabetes on vascular response of rabbit carotid artery to acetylcholine (Ach). We compared the Ach-induced relaxant response of isolated arterial segments obtained from both control and diabetic animals. To assess the influence of the endothelium, this cell layer was mechanically removed in some of the arterial segments ("rubbed arteries") from each experimental group. Ach induced a concentration-related endothelium-mediated… CONTINUE READING

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