Influence of experimental diabetes on brain levels of monoamine neurotransmitters and their precursor amino acids during tryptophan loading

@article{Masiello1987InfluenceOE,
  title={Influence of experimental diabetes on brain levels of monoamine neurotransmitters and their precursor amino acids during tryptophan loading},
  author={Pellegrino Masiello and Ettore Balestreri and Domenico Bacciola and Ettore Bergamini},
  journal={Acta diabetologia latina},
  year={1987},
  volume={24},
  pages={43-50}
}
The variations in serum and brain concentrations of the large neutral amino acids and the simultaneous changes in brain levels of monoamine neurotransmitters have been studied in normal and streptozotocin-diabetic rats after tryptophan loading. An impaired acute accumulation of tryptophan and serotonin in the brain of diabetic ras was observed, concomitantly with a much faster disappearance of the administered tryptophan from the bloodstream in these animals than in controls. Following the… CONTINUE READING

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