Influence of ethylene oxide gas treatment on the in vitro degradation behavior of dermal sheep collagen.

@article{OldeDamink1995InfluenceOE,
  title={Influence of ethylene oxide gas treatment on the in vitro degradation behavior of dermal sheep collagen.},
  author={L. H. H. Olde Damink and Pieter J Dijkstra and Marja J. A. van Luyn and Pauline B van Wachem and Paul Nieuwenhuis and Jan Feijen},
  journal={Journal of biomedical materials research},
  year={1995},
  volume={29 2},
  pages={
          149-55
        }
}
The influence of ethylene oxide gas treatment on the in vitro degradation behavior of noncrosslinked, glutaraldehyde crosslinked or hexamethylene diisocyanate crosslinked dermal sheep collagen (DSC) using bacterial collagenase is described. The results obtained were compared with the degradation behavior of either nonsterilized or gamma-sterilized DSC. Upon ethylene oxide sterilization, reaction of ethylene oxide with the free amine groups of DSC occurred, which resulted in a decreased helix… 
View on PubMed
ris.utwente.nl
76 Citations
Highly Influential Citations
5
Background Citations
22
Methods Citations
5
Results Citations
1

Figures and Tables from this paper

76 Citations

Citation Type

Citation Type

In vitro degradation of dermal sheep collagen cross-linked using a water-soluble carbodiimide.
The effect of Ethylene Oxide Sterilisation, Beta Irradiation and Gamma Irradiation on Collagen Fibril-Based Scaffolds.
TLDR
Sterilisation methods had hardly any effect on tensile strength of crosslinked scaffolds, but -surprisingly- they increased the tensiles strength of non-cross linked scaffolds.
Polymer Degradation and Stability
TLDR
The results suggest that the biodegradable composites can release high concentrations of antibiotics (well above the minimum inhibitory concentration) in-vitro for up to 28 days after g irradiation of less than 25 kGy.
The influence of γ irradiation and ethylene oxide treatment on the release characteristics of biodegradable poly(lactide-co-glycolide) composites
INVESTIGATION INTO THE STRUCTURAL INTEGRITY OF COLLAGEN BASED DRUG DELIVERY SYSTEMS AFTER EXPOSURE TO ETHYLENE OXIDE AND GAMMA STERILISATION TECHNIQUES
TLDR
Hydration studies have shown that, the EtO sterilised collagen sponge absorbed the greatest amount of deionised water after a period of 3 days, while the gamma sterilised gentamicin sulphate sponge completely dissolved after 24 hours, a good indication that gamma sterilisation breaks down cross-links or larger chains of the material, thus reducing the mechanical integrity of the sponge.
In vitro study of enzymatic degradation of biological tissues fixed by glutaraldehyde or epoxy compound.
TLDR
Microcalorimetric analysis of collagenase degradation of fresh, epoxy-fixed, and glutaraldehyde-fixed tissues revealed that the heat released during degradation correlates well with the degree of tissue degraded.
The impact of vacuum freeze-drying on collagen sponges after gas plasma sterilization
TLDR
The results show the substantial impact of sterilization of porous materials made for tissue engineering by achieving faster decontamination of the remaining H2O2 following vacuum freeze-drying following gas plasma sterilization.
Effect of the sterilization method on the performance of collagen type I on chronic wound parameters in vitro.
  • C. Wiegand, M. Abel, +4 authors U. Hipler
  • Biology, Medicine
    Journal of biomedical materials research. Part B, Applied biomaterials
  • 2009
TLDR
Although a pronounced effect on the physical properties of the collagen was found, there was no significant loss in the binding affinity for polymorphonuclear elastase, matrix metalloproteinase-2, and interleukin-1beta, or in the antioxidant capacity.
Influence of Cross-Linking Method and Disinfection/Sterilization Treatment on the Structural, Biophysical, Biochemical, and Biological Properties of Collagen-Based Devices.
TLDR
The data illustrate that the cross-linking method and the disinfection/sterilization treatment differentially affect the structural, biophysical, biochemical, and biological properties of collagen-based devices, and thus, they should be optimized according to the clinical indication.
Cross-linking with acid chlorides improves thermal and mechanical properties of collagen based biopolymer material
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Changes in the mechanical properties of dermal sheep collagen during in vitro degradation.
The changes in tensile strength, elongation at break, and high strain modulus of dermal sheep collagen (DSC) during in vitro degradation using bacterial collagenase were studied. The changes in…
Effect of collagen crosslinking on the rate of resorption of implanted collagen tubing in rabbits.
TLDR
Collagen tubes tanned for shorter time periods and sterilized with propylene oxide were more resistant to degradation than those sterilization with irradiation, and this difference was absent, however, with material taned for longer times.
Enhancement of the kinetics of the aeration of ethylene oxide sterilized polymers using microwave radiation.
TLDR
The relative efficiency of microwave desorption compared to conventional aeration offers considerable gains in the cost-effectiveness of gas sterilization since it will permit a much greater throughput of material, thereby obviating the need for excessively large inventories of equipment.
Glutaraldehyde as a crosslinking agent for collagen-based biomaterials
The formation of Schiff bases during crosslinking of dermal sheep collagen (DSC) with glutaraldehyde (GA), their stability and their reactivity towards GA was studied. All available free amine groups…
Aeration of ethylene oxide-sterilized polymers.
Crosslinking of dermal sheep collagen using hexamethylene diisocyanate
The use of hexamethylene diisocyanate (HMDIC) as a crosslinking agent for dermal sheep collagen (DSC) was studied. Because HMDIC is only slightly water soluble, a surfactant was used to obtain a…
The effect of gamma-irradiation on collagen molecules, isolated alpha-chains, and crosslinked native fibers.
TLDR
The enzyme digestion study showed that the material exposed to a very high dosage of radiation resisted degradation by pronase, however, molecular weight analysis showed a significant number of peptide bonds being cleaved by the radiation which could cause considerable changes in the long-term characteristics of the material.
The effect of modification on the susceptibility of collagen to proteolysis: I. Chemical modification of amino acid side chains.
Infrared spectroscopic study of polymers exposed to ethylene oxide.
Kinetic study of collagen fixation with polyepoxy fixatives.
TLDR
The overall fixation rate was found to be reaction-rate controlled, as the rate of fixation was relatively slow compared with the rateOf diffusion of PC, and the reaction rate was favored by a higher temperature, concentration, and solution pH.
...
1
2
3
...