Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice

@article{Zhu2009InfluenceOE,
  title={Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice},
  author={Shunwei Zhu and Alina Codita and Nenad Bogdanovic and Jens Hjerling-Leffler and Patrik Ernfors and Bengt Winblad and David W. Dickins and Abdul Kadir H Mohammed},
  journal={Behavioural Brain Research},
  year={2009},
  volume={197},
  pages={339-346}
}
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53 Citations
Highly Influential Citations
5
Background Citations
26
Results Citations
4

53 Citations

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Citation Type

The impact of environmental enrichment on sex-specific neurochemical circuitries – Effects on brain-derived neurotrophic factor and the serotonergic system
Altering BDNF expression by genetics and/or environment: Impact for emotional and depression-like behaviour in laboratory mice
Antidepressive and BDNF effects of enriched environment treatment across ages in mice lacking BDNF expression through promoter IV
TLDR
The results suggest that defective promoter IV causes depression-like behavior, regardless of age and gender, and that EET during ED is particularly beneficial to individuals with promoter IV-BDNF deficiency, while additional treatment may be needed for older adults.
Post-weaning environmental enrichment improves BDNF response of adult male rats
Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice.
TLDR
While reduced BDNF levels in general correlate with less efficient fear learning, this lack of BDNF can be compensated in young but not in older animals, suggesting that the cellular mechanisms responsible for fear learning consolidation become BDNF-dependent 3 mo after birth.
Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition.
TLDR
The combined data illustrate an apparent paradox in the role of the BDNF system in controlling complex behavior and suggest that the individual components may also engage independently in separate signaling pathways.
Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus
Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV
TLDR
It is demonstrated that enriched environment (EE) treatment rescued depression-like behavior, decreased BDNF levels and defective neurogenesis in the HIP caused by lack of promoter IV-driven BDNF expression, suggesting thatBDNF levels may be one of the key factors regulating depression and antidepressant effects through hippocampal neurogenisation.
Housing environment modulates physiological and behavioral responses to anxiogenic stimuli in trait anxiety male rats
Does the enriched environment alter memory capacity in malnourished rats by modulating BDNF expression?
TLDR
Evidence from the scientific literature suggests that the mechanisms of synaptic plasticity in the hippocampus of adult animals are influenced by malnutrition and EE, and these alterations may involve the participation of BDNF as a key regulator in memory processes in the adult animal hippocampus.
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References

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Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain
TLDR
Findings demonstrate significant alterations in NGF, BDNF, and NT-3 protein levels in several brain regions as a result of an enriched versus an isolated environment and thus provide a possible biochemical basis for behavioral and morphological alterations that have been found to occur with a shifting environmental stimulus.
Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats
Impact of enriched-environment housing on brain-derived neurotrophic factor and on cognitive performance after a transient global ischemia
Enhanced BDNF Signaling is Associated with an Antidepressant-like Behavioral Response and Changes in Brain Monoamines
TLDR
The data suggest that trkB activation may play a critical role in the behavioral responses to antidepressant drugs in mice, and that brain-derived neurotrophic factor influences the growth and plasticity of serotonergic neurons via the activation of trkB receptor.
Involvement of Brain-Derived Neurotrophic Factor in Spatial Memory Formation and Maintenance in a Radial Arm Maze Test in Rats
TLDR
The results suggest that BDNF plays an important role not only in the formation, but also in the retention and/or recall, of spatial memory.
Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice
Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic factor
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