Influence of environmental context on tolerance to LSD-induced behavior in primates

  title={Influence of environmental context on tolerance to LSD-induced behavior in primates},
  author={R. Francis Schlemmer and Carol Nawara and WILLIAM J. Heinze and John Manley Iii Davis and Claire D. Advokat},
  journal={Biological Psychiatry},
5 Citations
Tolerance to Lysergic Acid Diethylamide
In humans, mental tolerance to LSD substantially manifests 24 h after its first administration and reaches a maximum by around the fourth day, and in animals, LSD-induced shaking behavior, limb flicking, and hallucinogenic pausing are undermined by tolerance, too.
Drug and Alcohol Abuse
  • M. D.
  • Critical Issues in Psychiatry
  • 2000
Acute Effects of LSD on Rhesus Monkey Operant Test Battery Performance
In rhesus monkeys, performance of tasks believed to depend on aspects of time estimation and motivation are more sensitive to the acute disruptive effects of LSD than are tasks thought to model learning, short-term memory, and color and position discrimination.
Hallucinogens and Related Drugs
The drugs discussed in this chapter produce more intense changes and often yield abnormal sensory inputs of a predominantly visual nature (illusions or hallucinations), even at low doses.
Behavioral abnormalities induced by frontal cortical and nucleus accumbens lesions
Findings suggest that lesions in the dorsolateral frontal cortex and NAS may affect locomotor activity through a common mechanism mediated through the NAS.


Pavlovian conditional tolerance to haloperidol catalepsy: evidence of dynamic adaptation in the dopaminergic system.
It is demonstrated that Pavlovian conditioning factors determine the occurrence of tolerance to haloperidol catalepsy, and that an increase in the number of brain dopamine receptors cannot account for the conditional occurrence of such tolerance.
The role of Pavlovian processes in drug tolerance and dependence: implications for treatment.
It is proposed that extinction of cues which elicit conditional compensatory responses is an essential factor for treatment and that by virtue of prior Pavlovian conditioning, stress and depression may serve as cues to elicit conditional compensate responses and attendant craving.
Evidence for conditioned tolerance of the tail flick reflex.
  • C. Advokat
  • Medicine
    Behavioral and neural biology
  • 1980
Behavioral tolerance of the tail flick reflex to the analgesic action of morphine was significantly modified by the context in which the reflex was assessed. Animals tested in a familiar environment,
Dissociations between the effects of LSD on behavior and raphe unit activity in freely moving cats.
The hypothesis that the action of hallucinogenic drugs is mediated by a depression of the activity of brain serotonergic (raphe) neurons was tested by examining the behavioral effects of d-lysergic