Influence of endotoxin and lipid A on the renal handling and accumulation of gentamicin in rats.


The contribution of lipid A, an active component of endotoxin (LPS), to changes in the pharmacokinetics, renal handling and intrarenal accumulation of gentamicin induced by Klebsiella pneumoniae LPS was investigated in rats. Either LPS (250 micrograms/kg) or lipid A (equivalent to dose of LPS) was infused 2 h before the administration of gentamicin (10 mg… (More)


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