Influence of endothelium on beta-adrenoceptor-mediated mechanical and electrical functions in rat pulmonary artery.

@article{Mahajan2010InfluenceOE,
  title={Influence of endothelium on beta-adrenoceptor-mediated mechanical and electrical functions in rat pulmonary artery.},
  author={Puneet Mahajan and Reza Tabrizchi},
  journal={Vascular pharmacology},
  year={2010},
  volume={53 3-4},
  pages={144-50}
}
The effect of isoprenaline on mechanical and electrical functions was studied in intact and denuded rat isolated pulmonary arteries. In intact blood vessels, isoprenaline-induced relaxation was significantly attenuated by acidification of buffer, presence of Ba(2+) and/or ouabain. Isoprenaline produced hyperpolarisation of vascular muscle cells increasing E(m) from -61.0+/-0.44 (n=190 cells) to -70.0+/-0.74 mV (n=31 cells; mean+/-SE). The latter effect was inhibited by acidification of buffer… CONTINUE READING