Influence of endogenous prostaglandins on secretin-mediated inhibition of gastric acid secretion in dogs.

@article{Maclellan1988InfluenceOE,
  title={Influence of endogenous prostaglandins on secretin-mediated inhibition of gastric acid secretion in dogs.},
  author={D. Maclellan and J. Upp and J. Thompson},
  journal={Gastroenterology},
  year={1988},
  volume={95 3},
  pages={
          625-9
        }
}
The influence of endogenous prostaglandins on secretin-mediated inhibition of gastric acid secretion was examined in 6 mongrel dogs with Thomas gastric and Herrera pancreatic cannulas. The dogs were given intravenous pentagastrin (1 microgram/kg.h) during the 180-min experiment, and graded doses of secretin (0.3-1.5 micrograms/kg.h) (1-5 CU/kg.h) were infused intravenously between 60 and 120 min. In alternate, otherwise identical experiments, a prostaglandin synthesis inhibitor, either… Expand
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