Influence of embolism and imipramine on kinetics of serotonin uptake by dog lung.

@article{Rickaby1984InfluenceOE,
  title={Influence of embolism and imipramine on kinetics of serotonin uptake by dog lung.},
  author={David A. Rickaby and Christopher A. Dawson and John H. Linehan},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  year={1984},
  volume={56 5},
  pages={1170-7}
}
We previously presented a model from which the kinetic parameters Km and Vmax for serotonin uptake by the lung can be obtained from multiple indicator-dilution data. The purpose of the present study was to determine whether experimentally induced changes in lung endothelial function would be revealed in the kinetic parameters calculated using the model. In experiments using isolated dog lung lobes, embolization with 550-microns glass beads was used to reduce the vascular volume and perfused… CONTINUE READING

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