Influence of electrostatic interactions on the release of charged molecules from lipid cubic phases.

Abstract

The release of positive, negative, and neutral hydrophilic drugs from pH responsive bicontinuous cubic phases was investigated under varying conditions of electrostatic interactions. A weak acid, linoleic acid (LA), or a weak base, pyridinylmethyl linoleate (PML), were added to the neutral monolinolein (ML) in order to form lyotropic liquid-crystalline (LLC… (More)
DOI: 10.1021/la5008439

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