Influence of drugs acting on nitric oxide-dependent pathways on ethanol tolerance in rats

@article{Wazlawik2003InfluenceOD,
  title={Influence of drugs acting on nitric oxide-dependent pathways on ethanol tolerance in rats},
  author={Elisabeth Wazlawik and Gina Struffaldi Morato},
  journal={Psychopharmacology},
  year={2003},
  volume={170},
  pages={343-350}
}
Our previous studies have shown that the inhibition of nitric oxide (NO) synthesis with drugs administered either by systemic or ICV routes blocks the development of tolerance to some of the effects of ethanol. The aim of this study was to further investigate the role of NO-dependent pathways in tolerance to the incoordinating effect of ethanol through ICV administration of drugs that activate or interfere with NO-dependent pathways. Male Wistar rats were pretreated with IP ethanol (2.7 g/ kg… CONTINUE READING