• Chemistry, Medicine
  • Published in
    Journal of pharmaceutical…
    2011
  • DOI:10.1002/jps.22655

Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors.

@article{Griffin2011InfluenceOD,
  title={Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors.},
  author={Latoya Griffin and Pieter Annaert and Kim L R Brouwer},
  journal={Journal of pharmaceutical sciences},
  year={2011},
  volume={100 9},
  pages={
          3636-54
        }
}
Protease inhibitors, a class of antiretroviral agents frequently used in the treatment of HIV infection, interact with numerous transport proteins resulting in clinically significant drug-drug interactions (DDIs). This review focuses on the proteins that transport protease inhibitors and directly influence the pharmacokinetics of these drugs, as well as the transport proteins that are inhibited or induced by protease inhibitors. Clinically relevant DDIs involving drug transporters and protease… CONTINUE READING

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