Influence of drug lipophilicity on terpenes as transdermal penetration enhancers.

  title={Influence of drug lipophilicity on terpenes as transdermal penetration enhancers.},
  author={Donald A Godwin and Bozena Michniak},
  journal={Drug development and industrial pharmacy},
  volume={25 8},
Percutaneous absorption-enhancing effects on the skin of hairless mice of 11 monoterpenes [1, (+)-limonene; 2, (-)-menthone; 3, (+)-terpinen-4-ol; 4, alpha-terpineol; 5, 1,8-cineole; 6, (+)-carvone; 7, (-)-verbenone; 8, (-)-fenchone; 9, p-cymene; 10, (+)-neomenthol; and 11, geraniol] were investigated using three different model drugs (caffeine, hydrocortisone, triamcinolone acetonide [TA]) with varying lipophilicities. Terpenes were applied at 0.4 M in propylene glycol (PG) to mouse skin. The… CONTINUE READING


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