Influence of dose size on the disposition of trans-[methoxy-14C]anethole in human volunteers.

@article{Caldwell1988InfluenceOD,
  title={Influence of dose size on the disposition of trans-[methoxy-14C]anethole in human volunteers.},
  author={John Caldwell and James D. Sutton},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1988},
  volume={26 2},
  pages={
          87-91
        }
}
  • J. Caldwell, J. D. Sutton
  • Published 1988
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers.
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the
Metabolism of anethole. I. Pathways of metabolism in the rat and mouse.
The metabolism of p-propylanisole in the rat and mouse and its variation with dose.
The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects.
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The amounts of the metabolites in the urine in normal men and in responding and non- Responding patients were quantitatively similar, except in one non-responding patient who converted nearly two-thirds of the absorbed drug into amines and ketones.
Metabolism of [14C]methamphetamine in man, the guinea pig and the rat
TLDR
The main reaction in the rat was aromatic hydroxylation, in the guinea pig demethylation and deamination, whereas in man much of the drug, possibly one-half, was excreted unchanged, and Marked species differences in the metabolism of methamphetamine were observed.
Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.
TLDR
Twenty-three naturally occurring and synthetic alkenylbenzene derivatives structurally related to the hepatocarcinogen safrole were assayed for their hepatocARCinogenicity in mice to identify benign skin tumors that could be promoted with croton oil.