Influence of dose size on the disposition of trans-[methoxy-14C]anethole in human volunteers.

@article{Caldwell1988InfluenceOD,
  title={Influence of dose size on the disposition of trans-[methoxy-14C]anethole in human volunteers.},
  author={John Caldwell and James D. Sutton},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1988},
  volume={26 2},
  pages={
          87-91
        }
}
  • J. Caldwell, J. D. Sutton
  • Published 1988
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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25 Citations
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25 Citations

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The current knowledge and the uncertainties impeding a conclusive evaluation of adverse effects to human health possibly resulting from consumption of foods containing alkenylbenzenes are discussed, especially focusing on the genotoxic compounds, safrole, methyleugenol, and estragole.
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Certain alkenylbenzenes (AB), flavoring chemicals naturally occurring in spices and herbs, are established to be cytotoxic and hepatocarcinogenic in rodents, and the DNA damaging potential of key representatives of this class was determined using the Turkey Egg Genotoxicity Assay.
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Although the daily intake of herbs and spices is very low compared to most other foods, this important set of food seasoning agents should not be underestimated, especially given their potential benefits to human health.
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References

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Metabolism of anethole. II. Influence of dose size on the route of metabolism of trans-anethole in the rat and mouse.
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  • Medicine, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1984
The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers.
1. The metabolic fates of the naturally occurring food flavours trans-anethole and estragole, and their synthetic congener p-propylanisole, have been investigated in human volunteers using the…
Metabolism of anethole. I. Pathways of metabolism in the rat and mouse.
The metabolism of p-propylanisole in the rat and mouse and its variation with dose.
The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects.
TLDR
The amounts of the metabolites in the urine in normal men and in responding and non- Responding patients were quantitatively similar, except in one non-responding patient who converted nearly two-thirds of the absorbed drug into amines and ketones.
Metabolism of [14C]methamphetamine in man, the guinea pig and the rat
TLDR
The main reaction in the rat was aromatic hydroxylation, in the guinea pig demethylation and deamination, whereas in man much of the drug, possibly one-half, was excreted unchanged, and Marked species differences in the metabolism of methamphetamine were observed.
Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.
TLDR
Twenty-three naturally occurring and synthetic alkenylbenzene derivatives structurally related to the hepatocarcinogen safrole were assayed for their hepatocARCinogenicity in mice to identify benign skin tumors that could be promoted with croton oil.
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Food flavourings and compounds of related structure. II. Subacute and chronic toxicity.