Influence of dose and sex on the disposition and hepatic effects of cinnamyl anthranilate in the B6C3F1 mouse.

@article{Caldwell1985InfluenceOD,
  title={Influence of dose and sex on the disposition and hepatic effects of cinnamyl anthranilate in the B6C3F1 mouse.},
  author={John Caldwell and A Anthony and Ian A. Cotgreave and S. A. Sangster and James D. Sutton and Bruce K. Bernard and Richard A. Ford},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1985},
  volume={23 6},
  pages={
          559-66
        }
}
  • J. Caldwell, A. Anthony, R. A. Ford
  • Published 1 June 1985
  • Biology
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
10 Citations
Factors affecting the metabolism of cinnamyl anthranilate in the rat and mouse.
  • F. Keyhanfar, J. Caldwell
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1996
Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose.
  • B. Nutley, P. Farmer, J. Caldwell
  • Medicine, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1994
Comparison of the Effects of Cinnamyl Anthranilate on Hepatic Peroxisome Proliferation and Cell Replication in the Rat and Mouse
TLDR
A marked species difference between the hepatic effects of CA is demonstrated in female B6C3F1mice and female F344 rats and the formation of liver tumors in long-term studies appears to be attributable to a sustained stimulation of both peroxisome proliferation and cell replication in mouse hepatocytes.
Cinnamyl anthranilate causes coinduction of hepatic microsomal and peroxisomal enzymes in mouse but not rat.
TLDR
It is suggested that in mice, peroxisomal proliferation occurs only at doses high enough to prevent complete metabolic hydrolysis, and in rats fewer and smaller changes were seen with little or no evidence of peroxISomal proliferation at the doses used.
Studies on benzyl acetate. I. Effect of dose size and vehicle on the plasma pharmacokinetics and metabolism of [methylene-14C]benzyl acetate in the rat.
  • M. Chidgey, J. Caldwell
  • Chemistry, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1986
RIFM fragrance ingredient safety assessment, phenylethyl anthranilate, CAS Registry Number 133-18-6.
  • A. Api, D. Belsito, S. Tsang
  • Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2020
The Safety of Flavorings
The nutritional requirements of humans can be met by a nearly endless variety of sources. Food is not merely a biological necessity, but also an aesthetic experience and a cultural expression. The
Recent progress in the consideration of flavoring ingredients under the Food Additives Amendment. 15. GRAS substances.
Liste des composes aromatiques generalement consideres comme sans danger par un jury d'expert de l'Association des fabricants d'aromes et d'extraits (Etats Unis)

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