Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat

@article{Caccia2005InfluenceOD,
  title={Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat},
  author={S. Caccia and M. Cappi and C. Fracasso and S. Garattini},
  journal={Psychopharmacology},
  year={2005},
  volume={100},
  pages={509-514}
}
Fluoxetine (FL) is being used in neuropharmacology as a tool for studying various functional roles of serotoninergic neurons. Its kinetics was studied in rats, a species widely used in neurochemical studies, after IV (2.5–10 mg/kg) and oral (5–20 mg/kg) administration. When injected IV the drug followed apparent first-order kinetics up the 10 mg/kg dose. Its volume of distribution was large and total body clearance was relatively high compared to liver blood flow. The mean elimination half… Expand
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