Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures.

@article{Huster1998InfluenceOD,
  title={Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures.},
  author={Daniel Huster and Klaus Arnold and Klaus Gawrisch},
  journal={Biochemistry},
  year={1998},
  volume={37 49},
  pages={17299-308}
}
We investigated lateral lipid organization in membranes with a lipid composition relevant to neural and retinal membranes [phosphatidylcholine (PC)/phosphatidylethanolamine (PE)/phosphatidylserine (PS)/cholesterol, 4/4/1/1, mol/mol/mol/mol]. The mixed-chain phospholipids contained saturated stearic acid (18:0) in the sn-1 position and the monounsaturated oleic acid (18:1) or polyunsaturated docosahexaenoic acid (22:6) in sn-2. Lateral lipid organization was evaluated by 2H NMR order parameter… CONTINUE READING

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