Influence of disease manifestation and antineutrophil cytoplasmic antibody titer on the response to pulse cyclophosphamide therapy in patients with Wegener's granulomatosis.

@article{ReinholdKeller1994InfluenceOD,
  title={Influence of disease manifestation and antineutrophil cytoplasmic antibody titer on the response to pulse cyclophosphamide therapy in patients with Wegener's granulomatosis.},
  author={Eva Reinhold-Keller and Joern Kekow and Armin Schnabel and Wilhelm H. Schmitt and Martin Heller and Andrea Beigel and Gernot I W Duncker and Wolfgang Ludwig Gross},
  journal={Arthritis and rheumatism},
  year={1994},
  volume={37 6},
  pages={919-24}
}
OBJECTIVE To assess the effectiveness of pulse cyclophosphamide (CYC) in the treatment of Wegener's granulomatosis (WG) and to identify the patients who are responsive to the treatment. METHODS The prospective study included 43 patients with biopsy-proven WG. Clinical, radiographic, laboratory, and immunologic data were evaluated for predictive values regarding the outcome of pulse CYC therapy. RESULTS Only 42% of the patients showed complete or partial remission that lasted at least 6… CONTINUE READING

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