Influence of different indwelling lines on the measurement of blood cyclosporin A levels.

@article{Carreras1988InfluenceOD,
  title={Influence of different indwelling lines on the measurement of blood cyclosporin A levels.},
  author={Enric Carreras and Maria Angeles Jimenez Lozano and Ram{\'o}n Deulofeu and Simon Roman and Albert Gra{\~n}ena and Ciril Rozman},
  journal={Bone marrow transplantation},
  year={1988},
  volume={3 6},
  pages={637-9}
}
We studied in vivo and in vitro the possible influence of the indwelling line on the measurement of cyclosporin A (CSA) levels. CSA levels measured in samples taken from the catheter lumen used for CSA administration were significantly higher than those taken either from a second lumen or from a peripheral vein. Reversible fixation of the drug to the catheter walls might explain this alteration. The degree of fixation varies for different types of plastic material.