Influence of dietary substances on intestinal drug metabolism and transport.

@article{Won2010InfluenceOD,
  title={Influence of dietary substances on intestinal drug metabolism and transport.},
  author={Christina S Won and Nicholas H Oberlies and Mary Paine},
  journal={Current drug metabolism},
  year={2010},
  volume={11 9},
  pages={778-92}
}
Successful delivery of promising new chemical entities via the oral route is rife with challenges, some of which cannot be explained or foreseen during drug development. Further complicating an already multifaceted problem is the obvious, yet often overlooked, effect of dietary substances on drug disposition and response. Some dietary substances, particularly fruit juices, have been shown to inhibit biochemical processes in the intestine, leading to altered pharmacokinetic (PK), and potentially… CONTINUE READING
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