Influence of dialysis on prednisolone kinetics.

  title={Influence of dialysis on prednisolone kinetics.},
  author={Staffan Bj{\"o}rck and Jarl Ahlm{\'e}n and T. Mellstrand and G Stelin},
  journal={Acta medica Scandinavica},
  volume={215 4},
Six patients with end-stage renal disease were given prednisolone, 0.7-1.0 mg/kg/b.wt. parenterally. Prednisolone kinetics were investigated during dialysis, in 3 patients on hemodialysis and in 3 on continuous peritoneal dialysis, and also on days without dialysis. Mean plasma half-life was 250 min in five patients and 690 min in one patient who also suffered from intermittent porphyria. No change was found in prednisolone kinetics when the dialysis-free period was compared to the dialysis… CONTINUE READING