Influence of dextran infusion on the pulmonary hypertensive effect of concentrated saline.

  • R C READ, James A. Vick, M W MEYER
  • Published 1961 in Circulation research


B and Burstein 1 reported in 1951 that the intravenous administration of concentrated saline produces pulmonary hypertension in the dog. The response was attributed to arteriospasm since it could be elicited in the isolated perfused lung. Eliakim and his associates aroused considerable interest in this phenomenon when they suggested in 1958 that its mechanism was pulmonary venoconstriction evoked by the rise in blood sodium-ion concentration. This interpretation was questioned by Semler, Shepherd, and Swan who reported that the site of obstruction was proximal to the capillary bed. However, Read and his colleagues" obtained evidence for an associated pulmonaryvenous-left-atrial pressure difference in all but a minority of experiments. Eliakim et al." now agree that pulmonary-venous obstruction is not uniformly demonstrable in the presence of salt-induced obstruction to blood flow through the lungs. A further objection to the sodium-ion receptor theory is the observation that 50 per cent glucose initiates changes in the pulmonary vasculature essentially the same as those seen with isosmotic sodium chloride. An alternative hypothesis was developed to explain the absence of pulmonary reactivity to concentrated salt solutions when

Cite this paper

@article{READ1961InfluenceOD, title={Influence of dextran infusion on the pulmonary hypertensive effect of concentrated saline.}, author={R C READ and James A. Vick and M W MEYER}, journal={Circulation research}, year={1961}, volume={9}, pages={1240-6} }