Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid.

@article{Nasr2003InfluenceOC,
  title={Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid.},
  author={Payman Nasr and Hemamalini I Gursahani and Zhen Pang and Vimala Bondada and Jaewon Lee and Robert W. Hadley and James W. Geddes},
  journal={Neurochemistry international},
  year={2003},
  volume={43 2},
  pages={89-99}
}
3-Nitropropionic acid (3NP), an irreversible inhibitor of succinate dehydrogenase, induces both rapid necrotic and slow apoptotic death in rat hippocampal neurons. Low levels of extracellular glutamate (10 microM) shift the 3NP-induced cell death mechanism to necrosis, while NMDA receptor blockade results in predominantly apoptotic death. In this study, we examined the 3NP-induced alterations in free cytosolic and mitochondrial calcium levels, ATP levels, mitochondrial membrane potential, and… CONTINUE READING

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