Influence of cytoskeletal structure and mechanics on epithelial cell injury during cyclic airway reopening.

@article{Yalcin2009InfluenceOC,
  title={Influence of cytoskeletal structure and mechanics on epithelial cell injury during cyclic airway reopening.},
  author={Huseyin Cagatay Yalcin and Melissa K Hallow and J Wang and Mike Wei and H. Daniel Ou-Yang and Samir N Ghadiali},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2009},
  volume={297 5},
  pages={L881-91}
}
Although patients with acute respiratory distress syndrome require mechanical ventilation, these ventilators often exacerbate the existing lung injury. For example, the cyclic closure and reopening of fluid-filled airways during ventilation can cause epithelial cell (EpC) necrosis and barrier disruption. Although much work has focused on minimizing the injurious mechanical forces generated during ventilation, an alternative approach is to make the EpC less susceptible to injury by altering the… CONTINUE READING

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