Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation.

@article{Lindholm1993InfluenceOC,
  title={Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation.},
  author={Anna K. Lindholm and Barry D. Kahan},
  journal={Clinical pharmacology and therapeutics},
  year={1993},
  volume={54 2},
  pages={205-18}
}
To assess the importance of cyclosporine pharmacokinetics on graft outcome and acute rejection episodes, pretransplant and a total of 1868 posttransplant whole-blood cyclosporine pharmacokinetic profiles were performed in 160 consecutive kidney transplant recipients. The following posttransplant pharmacokinetic risk factors were associated with a poorer graft survival and a higher incidence of acute rejection: F, < 25%; clearance, > 325 ml/min; steady-state cyclosporine concentrations, < 350 ng… CONTINUE READING