Influence of cyclosporine A on protein synthesis in rat liver.

  title={Influence of cyclosporine A on protein synthesis in rat liver.},
  author={Lars A B{\"a}ckman and E. L. Appelkvist and Gustav Dallner},
  journal={Experimental and molecular pathology},
  volume={49 1},
The influence of the immunosuppressive agent cyclosporine A on protein synthesis was investigated in rat liver in vivo and in vitro. Incorporation of [14C]leucine into total protein by microsomes was inhibited 36% in the presence of cyclosporine A. Treatment of rats with cyclosporine A also resulted in decreased protein synthesis by microsomes isolated from the same animals. This inhibition was dependent on the dose administered and the duration of treatment. The inhibitory factor in this… CONTINUE READING

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