Influence of cyclooxygenase-2 (COX-2) gene promoter polymorphism -765 on graft loss after renal transplantation.

Abstract

A G-->C polymorphism has been identified in the human cyclooxygenase-2 (COX-2) gene promoter at position -765 with C allele leading to a decreased promoter activity with low prostaglandin E2 (PGE2) production. PGE2 has strong immunomodulatory properties that could influence graft survival. We studied the association between this polymorphism and allograft… (More)
DOI: 10.1111/j.1600-6143.2009.02830.x

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@article{Courivaud2009InfluenceOC, title={Influence of cyclooxygenase-2 (COX-2) gene promoter polymorphism -765 on graft loss after renal transplantation.}, author={C{\'e}cile Courivaud and Jamal Bamoulid and Andr{\'e} Loupy and Mich{\'e}le Deschamps and Claude Ferrand and Delphine Le Corre and Pierre Tiberghien and J. Chalopin and Christophe M Legendre and Eric Thervet and Patrick D Saas and Dominique Ducloux}, journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons}, year={2009}, volume={9 12}, pages={2752-7} }