Influence of cyclodextrin ring substituents on folding-related aggregation of bovine carbonic anhydrase.

@article{Sharma2001InfluenceOC,
  title={Influence of cyclodextrin ring substituents on folding-related aggregation of bovine carbonic anhydrase.},
  author={Loretta Sharma and Amit Sharma},
  journal={European journal of biochemistry},
  year={2001},
  volume={268 8},
  pages={2456-63}
}
A common obstacle to proper renaturation of an unfolded protein is aggregation, an intermolecular side reaction of immense importance in biotechnology and in the pathogenesis of several neurodegenerative diseases. Cyclic sugars known as cyclodextrins have been used as protein-folding aids. The effect of cyclodextrin chemistry on aggregation and refolding of carbonic anhydrase was evaluated in this study. Size-exclusion HPLC showed that cyclodextrins inhibit aggregate formation without… CONTINUE READING

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