Influence of cross-linked hyaluronic acid hydrogels on neurite outgrowth and recovery from spinal cord injury.

  title={Influence of cross-linked hyaluronic acid hydrogels on neurite outgrowth and recovery from spinal cord injury.},
  author={Eric M. Horn and Michael Beaumont and Xiao Zheng Shu and Adrian Harvey and Glenn D. Prestwich and Kris M. Horn and Alan R. Gibson and Mark C. Preul and Alyssa Panitch},
  journal={Journal of neurosurgery. Spine},
  volume={6 2},
OBJECT Therapies that use bioactive materials as replacement extracellular matrices may hold the potential to mitigate the inhibition of regeneration observed after central nervous system trauma. Hyaluronic acid (HA), a nonsulfated glycosaminoglycan ubiquitous in all tissues, was investigated as a potential neural tissue engineering matrix. METHODS Chick dorsal root ganglia were cultured in 3D hydrogel matrices composed of cross-linked thiol-modified HA or fibrin. Samples were cultured and… 

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