Influence of cross-link structure, density and mechanical properties in the mesoscale deformation mechanisms of collagen fibrils

@inproceedings{Depalle2015InfluenceOC,
  title={Influence of cross-link structure, density and mechanical properties in the mesoscale deformation mechanisms of collagen fibrils},
  author={Baptiste Depalle and Zhao Qin Qin and S. J. Shefelbine and Markus J Buehler},
  booktitle={Journal of the mechanical behavior of biomedical materials},
  year={2015}
}
Collagen is a ubiquitous protein with remarkable mechanical properties. It is highly elastic, shows large fracture strength and enables substantial energy dissipation during deformation. Most of the connective tissue in humans consists of collagen fibrils composed of a staggered array of tropocollagen molecules, which are connected by intermolecular cross-links. In this study, we report a three-dimensional coarse-grained model of collagen and analyze the influence of enzymatic cross-links on… CONTINUE READING

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Most of the connective tissue in humans consists of collagen fibrils composed of a staggered array of tropocollagen molecules , which are connected by intermolecular cross - links .
Most of the connective tissue in humans consists of collagen fibrils composed of a staggered array of tropocollagen molecules , which are connected by intermolecular cross - links .
The fibril mechanical response is characterized by : ( i ) an initial elastic deformation corresponding to the collagen molecule uncoiling , ( ii ) a linear regime dominated by molecule sliding and ( iii ) the second stiffer elastic regime related to the stretching of the backbone of the tropocollagen molecules until the fibril ruptures .
Most of the connective tissue in humans consists of collagen fibrils composed of a staggered array of tropocollagen molecules , which are connected by intermolecular cross - links .
The fibril mechanical response is characterized by : ( i ) an initial elastic deformation corresponding to the collagen molecule uncoiling , ( ii ) a linear regime dominated by molecule sliding and ( iii ) the second stiffer elastic regime related to the stretching of the backbone of the tropocollagen molecules until the fibril ruptures .
Most of the connective tissue in humans consists of collagen fibrils composed of a staggered array of tropocollagen molecules , which are connected by intermolecular cross - links .
The fibril mechanical response is characterized by : ( i ) an initial elastic deformation corresponding to the collagen molecule uncoiling , ( ii ) a linear regime dominated by molecule sliding and ( iii ) the second stiffer elastic regime related to the stretching of the backbone of the tropocollagen molecules until the fibril ruptures .
Most of the connective tissue in humans consists of collagen fibrils composed of a staggered array of tropocollagen molecules , which are connected by intermolecular cross - links .
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