Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES.

@article{OdremanMacchioli2000InfluenceOC,
  title={Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES.},
  author={F E Odreman-Macchioli and Sergio Tisminetzky and Michela Zotti and Francisco E. Baralle and Emanuele Buratti},
  journal={Nucleic acids research},
  year={2000},
  volume={28 4},
  pages={875-85}
}
Structural integrity of the hepatitus C virus (HCV) 5' UTR region that includes the internal ribosome entry site (IRES) element is known to be essential for efficient protein synthesis. The functional explanation for this observation has been provided by the recent evidence that binding of several cellular factors to the HCV IRES is dependent on the conservation of its secondary structure. In order to better define the relationship between IRES activity, protein binding and RNA folding of the… CONTINUE READING