Influence of contractile state on curvilinearity of in situ end-systolic pressure-volume relations.

@article{Kass1989InfluenceOC,
  title={Influence of contractile state on curvilinearity of in situ end-systolic pressure-volume relations.},
  author={David A. Kass and Rafael Beyar and Edward B. Lankford and Michael L Heard and W. Lowell Maughan and Kiichi Sagawa},
  journal={Circulation},
  year={1989},
  volume={79 1},
  pages={167-78}
}
Although in situ end-systolic pressure-volume relations (ESPVRs) are approximately linear throughout a limited load range, they often yield seemingly "negative" volume axis intercepts (V0) and V0 shifts with inotropic interventions. We tested whether or not these findings could stem from in situ ESPVR nonlinearity, and we examined the physiologic meaning and limitations of linearized ESPVR variables frequently used for assessing contractile state. Continuous left ventricular pressures and… CONTINUE READING