Influence of continuous veno-venous hemofiltration on argatroban clearance in a patient with septic shock

@article{Schusterschitz2008InfluenceOC,
  title={Influence of continuous veno-venous hemofiltration on argatroban clearance in a patient with septic shock},
  author={Nicola Schusterschitz and Romuald Bellmann and Michael V. Stein and Stefan Dunzendorfer and Christoph Pechlaner and Michael Joannidis},
  journal={Intensive Care Medicine},
  year={2008},
  volume={34},
  pages={1350-1351}
}
Sir: Argatroban, a direct thrombin inhibitor approved for heparin-induced thrombocytopenia (HIT), is primarily metabolized by the liver. Thus, dose adjustments are not recommended in renal failure [1, 2]. We report a patient with HIT and multiple organ dysfunction in whom anticoagulation by argatroban appeared to be substantially influenced by continuous veno-venous hemofiltration (CVVH). A 54-year-old woman with a history of rheumatoid arthritis and steroid therapy as well as peripheral… CONTINUE READING
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