Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.

@article{Uitendaal1984InfluenceOC,
  title={Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.},
  author={Martin P. Uitendaal and Jan H. Schornagel and Alberto Leyva and Herbert Michael Pinedo},
  journal={European journal of cancer \& clinical oncology},
  year={1984},
  volume={20 12},
  pages={
          1527-32
        }
}
Combinations of thymidine and inosine (ranging from 0 to 7.5 mg/hr) were co-administered during a 72-hr continuous i.v. infusion of 3 micrograms/hr methotrexate in normal and P388 solid tumor-bearing DBA/2 mice. Methotrexate alone was lethal to all normal mice. Inosine at 1.0-7.5 mg/hr could reverse toxicity up to 100% while thymidine at 0.5-7.5 mg/hr was less effective (less than or equal to 86% survival). Combinations of the nucleosides averted toxicity more effectively than either compound… Expand
Effect of hyperthermia and X-irradiation on survival and occurrence of metastases in mice bearing P388 tumor.
  • L. Perlaky, A. Fónagy, E. Unger, E. Hidvégi
  • Medicine
  • International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 1989
TLDR
Significant fewer metastases were observed in liver and spleen after hyperthermia and 5-10% metastasis occurred after transplantation of ascites tumor cells treated at 43.5 degrees C, and the possible alterations of P388 tumor cell membrane and surface proteins induced by in vitro hyperthermic treatment are discussed. Expand
Antitumor Effect of Nocardà ¬ arubra Cell Wall Skeleton on Syngeneically Transplanted P 388 Tumors
The antitumor activity of the immunomodulator, Nocardìarubra cell wall skeleton (N-CWS), was investigated using syngeneically trans planted P388 leukemia cells in a solid form. The s.c. growth ofExpand
Antitumor effect of Nocardia rubra cell wall skeleton on syngeneically transplanted P388 tumors.
TLDR
Findings indicate that macrophages are the main effector cells playing a critical role in the suppression of P388 tumor growth in DBA/2 mice, and that tumor necrosis factor produced by these cells may be involved in the macrophage-mediated cytostatic effect induced by N-CWS. Expand

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