Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.
@article{Uitendaal1984InfluenceOC, title={Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.}, author={M. Uitendaal and J. Schornagel and A. Leyva and H. Pinedo}, journal={European journal of cancer & clinical oncology}, year={1984}, volume={20 12}, pages={ 1527-32 } }
Combinations of thymidine and inosine (ranging from 0 to 7.5 mg/hr) were co-administered during a 72-hr continuous i.v. infusion of 3 micrograms/hr methotrexate in normal and P388 solid tumor-bearing DBA/2 mice. Methotrexate alone was lethal to all normal mice. Inosine at 1.0-7.5 mg/hr could reverse toxicity up to 100% while thymidine at 0.5-7.5 mg/hr was less effective (less than or equal to 86% survival). Combinations of the nucleosides averted toxicity more effectively than either compound… CONTINUE READING
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