Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.

M. Uitendaal; J. Schornagel; A. Leyva; H. Pinedo

DOI:10.1016/0277-5379(84)90146-9

Corpus ID: 24886294

Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.

@article{Uitendaal1984InfluenceOC,
  title={Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.},
  author={M. Uitendaal and J. Schornagel and A. Leyva and H. Pinedo},
  journal={European journal of cancer & clinical oncology},
  year={1984},
  volume={20 12},
  pages={
          1527-32
        }
}

M. Uitendaal, J. Schornagel, +1 author H. Pinedo

Published 1984

Biology, Medicine

European journal of cancer & clinical oncology

Combinations of thymidine and inosine (ranging from 0 to 7.5 mg/hr) were co-administered during a 72-hr continuous i.v. infusion of 3 micrograms/hr methotrexate in normal and P388 solid tumor-bearing DBA/2 mice. Methotrexate alone was lethal to all normal mice. Inosine at 1.0-7.5 mg/hr could reverse toxicity up to 100% while thymidine at 0.5-7.5 mg/hr was less effective (less than or equal to 86% survival). Combinations of the nucleosides averted toxicity more effectively than either compound… CONTINUE READING

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