Influence of compound structure on affinity, sequence selectivity, and mode of binding to DNA for unfused aromatic dications related to furamidine.

@article{Nguyen2002InfluenceOC,
  title={Influence of compound structure on affinity, sequence selectivity, and mode of binding to DNA for unfused aromatic dications related to furamidine.},
  author={Binh Nguyen and Christelle Tardy and Christian Bailly and Pierre Colson and Claude Houssier and Arvind Kumar and David W. Boykin and W. David Wilson},
  journal={Biopolymers},
  year={2002},
  volume={63 5},
  pages={
          281-97
        }
}
In the course of a program aimed at developing sequence-specific gene-regulatory small organic molecules, we have investigated the DNA interactions of a new series of nine diphenylfuran dications related to the antiparasitic drug furamidine (DB75). Two types of structural modifications were tested: the terminal amidine groups of DB75 were shifted from the para to the meta position, and the amidines were replaced with imidazoline or dimethyl-imidazoline groups, to test the importance of both the… CONTINUE READING

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