Influence of complement C5 and V beta T cell receptor mutations on susceptibility to collagen-induced arthritis in mice.

@article{Banerjee1989InfluenceOC,
  title={Influence of complement C5 and V beta T cell receptor mutations on susceptibility to collagen-induced arthritis in mice.},
  author={Sanjay Banerjee and Gary D. Anderson and Harvinder S. Luthra and Chella S. David},
  journal={Journal of immunology},
  year={1989},
  volume={142 7},
  pages={2237-43}
}
SWR/J mice are resistant to collagen-induced arthritis (CIA) despite having a susceptible H-2q haplotype. We have earlier demonstrated the possible role of the V beta TCR mutation of SWR in the resistance to CIA. To investigate the influence of the C5 deficiency of SWR in this resistance, crosses were made between SWR and A/J (C5 deficient, TCRwild, H-2a), and between SWR and C3H.A (C5 sufficient, TCRwild, H-2a). Upon immunization with bovine type II collagen in adjuvant, there was a similar… CONTINUE READING

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