Influence of combined use of selenious acid and SH compounds in parenteral preparations.

@article{Terada1997InfluenceOC,
  title={Influence of combined use of selenious acid and SH compounds in parenteral preparations.},
  author={Atsushi Terada and M. Yoshida and M Nakada and K Nakada and Noboru Yamate and Tsuneo Kobayashi and K Yoshida},
  journal={Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements},
  year={1997},
  volume={11 2},
  pages={
          105-9
        }
}
  • A. Terada, M. Yoshida, +4 authors K. Yoshida
  • Published 1997
  • Chemistry, Medicine
  • Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
The influence of the combined use of selenious acid and SH compounds (glutathione (GSH) and cysteine (Cys), or ascorbic acid (Asc)) on cultured venous vascular cells was investigated experimentally. When cultured human umbilical venous vascular endothelial cells were exposed to 10 microM of selenious acid combined with 0.5 mM-GSH or 0.5 mM-Cys, the release rates of [3H]-adenine and lactate dehydrogenase (LDH) from cells into the medium increased significantly as compared with after exposure to… Expand
2 Citations
Active oxygen species generation and cellular damage by additives of parenteral preparations: selenium and sulfhydryl compounds.
TLDR
Findings revealed that selenite generates AOS and causes cellular damage in the presence of sulfhydryl compounds, and it seems better to choose selenate or SeMet instead of selenites when a selenium compound is to be added to TPN. Expand
Selenium and selenoproteins: from endothelial cytoprotection to clinical outcomes.
TLDR
The role of the vascular endothelium in inflammation was demonstrated experimentally through biomarkers of endothelial dysfunction and cytoprotection and an increase in adhesion molecules and a decrease in the expression of selenoproteins following a decreased exposure to selenium are summarized. Expand

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