Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia.

@article{Small2009InfluenceOC,
  title={Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia.},
  author={Gary W. Small and Prabha Siddarth and Alison C. Burggren and Vladimir Kepe and Linda M. Ercoli and Karen J. Miller and Helen Lavretsky and Paul M. Thompson and G. M. Cole and Shih-Che Huang and Michael E. Phelps and Susan Y. Bookheimer and Jorge R. Barrio},
  journal={Archives of general psychiatry},
  year={2009},
  volume={66 1},
  pages={81-7}
}
CONTEXT Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer disease that accumulate in the brains of people without dementia years before they develop dementia. Positron emission tomography (PET) scans after intravenous injections of 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), which binds to plaques and tangles in vitro, demonstrate increased cerebral binding in patients with Alzheimer disease compared… CONTINUE READING