Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.

@article{Parker2007InfluenceOC,
  title={Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.},
  author={Alan L Parker and John H Mcvey and Jessica H Doctor and Oscar L{\'o}pez-Franco and Simon N Waddington and Menzo J. E. Havenga and Stuart A Nicklin and Andrew H. Baker},
  journal={Journal of virology},
  year={2007},
  volume={81 7},
  pages={3627-31}
}
Recent evidence supports a role for vitamin K-dependent coagulation zymogens in adenovirus serotype 5 (Ad5, subgroup C) infection of hepatocytes. Here, we assessed the effect of virus-zymogen interaction on cellular transduction using a panel of fiber (f)-pseudotyped viruses derived from subgroup D (f47, f33, f24, f45, f17, f30). Each virus directly bound factor X (FX) as determined by surface plasmon resonance, resulting in enhanced cell surface binding. Infection of HepG2 cells was promoted… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Adenovirus 5 fibers mutated at the KKTK putative HSPG binding site show restricted retargeting capacity when engineered with targeting peptides

  • A. Kritz, C. Nicol, +7 authors A. Baker
  • in the HI loop. Mol Ther,
  • 2007
1 Excerpt

after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease

  • D. Onion, N. K. Green, +7 authors K. D. Fisher
  • 2006

Similar Papers

Loading similar papers…